Axelerist

Author: cmdsonline

  • Lower Equipment Costs-for Clinical Trials

    Lower Equipment Costs-for Clinical Trials

    WHO CAN LOWER YOUR EQUIPMENT COSTS FOR CLINICAL TRIALS?

    Clinical trial studies are an essential part of pharmaceutical and biotechnology product development. Governed by strict protocols, these crucial tests ensure the safety of the public while confirming the reliability and effectiveness of manufactured drugs and medical devices. But the necessity of these trials can come at a steep price.

    Clinical trial equipment rentals can be a great way to loosen the budgetary constraints felt by most companies when starting their trials, and there are many providers that offer this type of service. However, sourcing a quality provider isn’t always easy. And since the majority of studies are completed in smaller environments with limited human resources, it’s important to work with a partner that can not only lower your equipment rental costs but also offers full-service support while managing the logistics of your trials from start to finish.

    So how do you know if you’re getting the value you need from your clinical trial equipment solutions provider? Here are a few things to consider when choosing the right company to work with.

    Competitive Equipment Rental Costs

    The financial investment to run a clinical trial is significant, so saving on medical equipment and supplies can make a positive impact on your budget allotments. However, while renting or leasing your clinical trial equipment on a regular payment schedule can save you a considerable amount of up-front capital, it’s important to ensure you are maintaining the lowest cost of ownership over time. To do this, it’s important to compare rates across multiple providers ensuring they can meet your short- and long-term financial goals.

    Axelerist is a clinical trial equipment leasing specialist that provides cost-effective solutions to organizations managing clinical trials. When compared against other providers in the industry, Axelerist offers the lowest prices available on new and used medical equipment and are experts at creating financially sustainable rental solutions for their clientele.

    Healthy Inventory Levels and Procurement Capabilities

    Clinical trial equipment suppliers typically only maintain a certain level of inventory on-hand, and this limits the level of service they can provide. Limited stock availability can sometimes force sponsors into having to work with multiple providers for the same clinical trial, or source and procure their own specialized materials. This can be a time-consuming and resource-heavy process and takes away from the financial benefits of getting your trial supplies and equipment from one main supplier.

    Axelerist helps companies eliminate these issues by keeping a large portfolio of equipment inventory at our U.S. and European depots. But more than just a provider of in-stock equipment, Axelerist is able to use their strong monetary resources to source any of the specialized equipment and resources you need to make your clinical trial a success. Whether your business needs access to centrifuges, EKG and ECG rentals, incubators, or high-quality cooling equipment turning to an Axelerist lease option is a smart choice for most sponsors.

    One thing to keep in mind is many suppliers don’t keep largescale equipment like Ultra-cold Freezers in stock at all times. When selecting a solution, keep that in mind that you may end up waiting weeks or months for a -86° freezer to be manufactured. That’s where Axelerist’s model differs. Axelerist has you covered and keeps a stock at all times of the typical items needed most by sponsors, including -86° Ultra-cold Freezers.

    Among other products, Axelerist is a provider of the ULT-25NE Ultra-Low Temperature Shuttle Freezer. For smaller laboratory spaces this Ultra-cold Freezer is a perfect blend of both maneuverability and energy-efficient cold-chain management. The equipment plugs into any outlet and maintains the smallest footprint in its class. And as your clinical trial needs scale, Axelerist gives you the ability to upgrade your smaller equipment for larger applications with quick turnaround times.

    Full-Service Support and Fast Lead Times

    Regardless of whether you purchase or lease your clinical trial equipment, the costs associated with initial installs, equipment calibration, and collection of materials pre- and post-trial adds up quickly. This doesn’t even consider the expense of having to upgrade equipment over time or transferring to new trial locations. It’s important to note that not all clinical trial suppliers feature the same level of service, and it’s in your best interest to align with one that can actively support your business objectives.

    Axelerist is dedicated to caring for all your lab equipment requirements, giving you back the time and resources you need to develop quality pharmaceutical products. They do this by providing the very best rates in clinical trial equipment rentals while including all associated shipping and collection costs. Their service also includes a full-time, dedicated project manager as a single point of contact for clients and an online portal for project details including shipping and tracking details.

    Axelerist is a global equipment rental service provider with over 30 years of experience serving the Life Sciences industry. They specialize in clinical trial equipment solutions and maintain a large quantity of on-hand inventory for all of your laboratory needs. If you’re interested in a cost-effective, sustainable way of managing your laboratory equipment needs, contact Axelerist today and speak with one of their industry experts.

  • Common Clinical Trial Delays and How To Avoid Them

    Common Clinical Trial Delays and How To Avoid Them

    Clinical trial delays have become the norm for the vast majority of drug research and development. Across the board, 8 out of 10 trials will face delays and 94 percent of delays are longer than one month.

    While even the briefest delay can significantly increase costs, others may impact long-term drug profitability or even result in failure.

    To reduce delays, it is important to first understand why they are so persistent and then evaluate and implement proactive solutions.

    Common Reasons for Delays Include:

    • Unmet or complicated compliance and regulatory standards
    • Procedure management gaps
    • Inefficient processes
    • Communication difficulties

    How to Be Proactive and Avoid Delays from the Start

    Although it’s impossible to account for all the unexpected challenges of an increasingly complex research environment, there are ways to minimize the odds of clinical trial delay.

    One obvious solution is ‘hands-on’ management. By establishing an open and close relationship with each study site, management is able to maintain optimal workflows while minimizing routine administrative challenges. It will become easier to react rapidly before a minor equipment problem turns into a considerable delay.

    Having a carefully planned study design in place, well-executed regulatory submission documents should be generated. This will not only keep the trial on schedule but also keep costs down.

    Finally, accurate data entry and integration is critical to ensure usability and avoid delays due to otherwise avoidable errors. Personnel responsible for data entry must be provided with sufficient training. Also, monitoring and control mechanisms should be put in place and data entry deadlines carefully tracked.

    Meeting Compliance and Regulatory Standards

    Another area that can cause otherwise avoidable clinical trial delays is the complexity of meeting compliance and regulatory standards.

    Pharmaceutical companies and academic institutions all have particular requirements for reviewing myriad aspects of a clinical trial. Issues arising from meeting these standards can cause considerable delays.

    Export compliance applies to everyone, and any organization that sends products, services or technology to foreign countries is subject to export control regulations.

    Regardless of what is exported, you need a comprehensive program in place that ensures you’re compliant in all areas to prevent time lost due to export violations holding up delivery.

    Furthermore, investigators can be significantly challenged by various state and federal regulatory requirements that can also adversely affect your trial’s timeline.

    Communication and Procedure Management

    The importance of communication and procedure management in avoiding clinical trial delays cannot be overstated.

    Effective communication is not only critical to explain the value of a trial to participants, funders, and other stakeholders, but will also ensure support for your research (and any future studies) in the region where the research is conducted. Avoiding miscommunications can also prevent misinformation causing overreactions that lead to otherwise avoidable delays.

    Communications are intimately linked to the conduct of the research and optimally, are addressed in the trial’s protocols and standard operating procedures.

    Procedure management itself is another mission-critical component to maintain the trial schedule, remain in compliance, and keep personnel on the same page as the study progresses.

    Proactively Reducing Delays Raises Odds of Success

    The research landscape grows increasingly difficult to navigate. Managers who proactively confront known challenges reduce the odds of costly delays that could significantly impact both time to market and a medication’s long-term profitability.

    A hands-on approach, training, and close monitoring of personnel will help prevent small problems from developing into considerable delays. Established standard operating procedures that include communications guidelines smooth processes and prevent delays due to negative public relations through misunderstanding of key facts about the research.

    Compliance and regulatory standards vary between academic institutions, pharmaceutical companies, and government agencies; investigators must meet these challenges head-on. By devoting the necessary resources to researching and meeting standards, delays caused by failing to meet these requirements are avoided.

    Outsourcing as a Solution

    Preventing clinical trial delay can consume time and resources better dedicated to the trial itself. Axelerist Financial provides project managers who will help you meet documentation and compliance requirements while seamlessly getting the equipment you need, where and when it’s needed.

  • COMPARING ANALYTICAL INSTRUMENTS: WHY PHARMA COMPANIES SHOULD CONSIDER LEASING

    COMPARING ANALYTICAL INSTRUMENTS: WHY PHARMA COMPANIES SHOULD CONSIDER LEASING

    Automated, advanced and flexible: These are identifiers we want when considering equipment that will increase overall efficiencies and bottom-line profitability. These attributes, however, also remind us of the ever-changing nature of the industry.

    There is an avoidable backdrop of regulatory protocols, nation-by-nation site requirements and technological advances to consider when making investments into new equipment. With change so rapid, leasing should be your primary strategy.

    Lease agreements offer flexibility, cost savings and are available on a range of equipment including analytical instruments. Below, our experts review what to look for when leasing Mass Spectrometers and Chromatographs.

    Mass Spectrometers

    Mass spectrometers identify the molecular composition and molar masses within a sample by selecting and electrifying the distinct particles. Pharmaceutical labs can benefit from these features:

  • Laser Desorption Ionization: Choosing a mass spectrometer starts by identifying the right ion source, the mechanism responsible for transmitting an electric field. This element will determine what samples your team can study. Life science experiments typically analyze particles with molar masses over 100,0000, such as polymers, proteins, and DNA fragments. Molecules of that size require matrix-assisted laser desorption/ionization (MALDI) or similar technology, which amplify laser wavelengths via conductive compound.
  • Flexibility: One of the easiest ways to reduce the operational complexity inherent to the research process is to work with customizable equipment. Your team may need to reconfigure the machine for unforeseen applications or upgrade the processing capabilities to streamline workflow.
  • Advanced data processing with an extensive spectral library: Biological samples contain the greatest potential array of molecules. You want to choose a software system capable of managing the volume of information produced during life science studies as well as a sample library with maximum identification capacity.
  • High-sensitivity detection: Due to its chemical complexity, organic specimens often contain trace elements that are challenging to distinguish. Make sure your mass spectrometer comes equipped with an exceedingly precise filtration system.

    • Chromatography Systems

    Chromatography systems remove elements from a complex mixture. Drug companies often use this machine to identify product contaminants, particularly toxic chiral compounds, which can be difficult to distinguish from their non-toxic counterparts. Research labs should seek the following:

  • Temperature control: Adjustable internal temperatures allow the investigator to maintain the integrity of temperature-sensitive samples.
  • Productivity enhancement: Today’s chromatography systems come with a range of automated features including robotic arms that move sample trays between compartments and self-monitoring processes for precise replicability. These features free up expensive labor while helping to eliminate the potential for human error.
  • Adaptability: A chromatography system, such as the Agilent 1200 Series HPLC System, is only as useful as the applications its able to serve. Adjustable settings, such as detector sensitivity and spectral resolution, and customizable, PC-compatible analytics software, go a long way to ensure your equipment can fulfill any protocol.

    • Leasing with a well-resourced supplier, such as Axelerist, allows you access to the most technologically advanced solutions at a rate that can be integrated into your budget and financial projections. We provide same day quotes, servicing and maintenance, and access to leading instrument manufacturers to laboratories around the world.

    Learn more about our simple, cost-effective leasing solutions.

  • Innovations in drug development

    Innovations in drug development

    HOW INNOVATIONS IN DRUG DEVELOPMENT COULD HELP THE PHARMACEUTICAL INDUSTRY SAVE BILLIONS

    The wave of innovation that’s benefited countless industries may finally reach drug development. A new report from the Economist Intelligence Unit (EIU) has identified four advancements in the design of clinical trials capable of tackling two of the industry’s longstanding challenges: patient recruitment and study completion.

    The report comes at a time when spending has reached an all-time high. According to a 2016 study by Tuft’s University, the cost to bring a drug to market totals $2.9 billion and has been increasing at a rate of 8.5 percent annually. While these figures have been subject to debate, a 2016 report by the U.S. Department of Health and Human Services acknowledges the cost is at least $1.2 billion. Yet, only 14 percent of drugs achieve FDA approval, according to recent estimates from MIT.

    How will pharmaceutical companies rein in expenses? The EIU analyzed emerging innovations using data from PubMed and Trialtrove. Here’s what they found.

    Adaptive Trials

    Adaptive trials allow for ongoing modifications by anticipating variants, such as drug dosage and cohort requirements. This innovation, which emerged in the 1990s, might be considered the most established of the group. Each year, a steady number of adaptive trials are added to PubMed after a 40 percent increase between 2010 and 2013. Furthermore, adaptive studies have been cited in recent drug approvals.

    According to the EIU report, adaptive trials outperformed conventional trials in almost all therapies with an average 13 percent increase in Phase II/III and a four-month decrease in recruitment time. Oncology trials saw the greatest benefit, a 36 percent increase in Phase II/III. The exception was rare disease studies, where adaptive trials were 18 percent less effective at reaching Phase II/III (this figure is based on eight trials).

    Patient-Centric Trials

    Patient-centric trials attempt to streamline recruitment and land higher quality cohorts by appealing to patients through technologies, such as online networks and remote data collection. Organizations promoting patient-centric trials have emerged across the U.S., E.U., China, and Japan.

    These studies cut recruitment times by an average of three months and were 19 percent more likely to launch, according to the EIU report. Rare disease trials, in particular, completed enrollment in 80 percent less time.

    Precision Medicine Trials

    Precision medicine trials target ideal patients based on their genetic markers. These studies generally increased their recruitment times by four months, but the select therapy verticals performed much better, with a five-month reduction for oncology and a 10-month reduction for rare disease.

    Real-World Data Trials

    Real-world data trials analyze the impact of therapies outside a clinical setting using big data sources, including electronic health records, disease registries, and health and medical devices. These trials have made headway across certain nations, particularly in China where disease registries and other health databases have rapidly expanded. While the use of big data in drug development holds enormous potential, these trials have been largely used in post-approval studies.

    The EIU found the number of real-world data trials cited in PubMed has increased by 300 percent since 2008. On average, these methodologies significantly increased (+21 percent) Phase II/III likelihood. However, recruitment time was minimally impacted and actually increased for oncology therapies.

    While the EIU report offers hope to pharmaceutical industries, the data is still relatively new and, therefore, limited. Nonetheless, these are emerging innovations to watch in years to come.

    For more on lab equipment, clinical trials, and leasing equipment news and trends visit the Axelerist Financial blog.

  • Impressive Benefits of Outsourcing Clinical Trial Equipment Rental

    Impressive Benefits of Outsourcing Clinical Trial Equipment Rental

    Outsourcing clinical trial equipment rental offers advantages that can speed up time to market and significantly aid in project management.

    The Benefits of Outsourcing Clinical Trial Equipment Rental

    A strong argument for clinical trial equipment rental is how much more affordable it can be when compared to the cost of buying. Purchasing equipment is not only expensive but may also make it difficult to see a return on that investment.

    The lower costs of equipment rental offer better financial leeway. Instead of a larger upfront cost, renting provides a regular payment schedule that can free up cash flow to be used in other areas. Additionally, accounting for depreciating assets is no longer a problem. You’ll be funding rentals from an operating expenditure budget rather than your capital expenditure budget.

    A critical factor in ensuring the success of a clinical trial is sourcing the right equipment. Rather than looking at unit costs for individual pieces of equipment, and dealing with multiple providers, trial equipment rental provides one-stop cost and time-saving services like:

  • Maintenance
  • Calibration services
  • Technical support
  • Equipment removal

    • The best rental equipment providers will offer cutting edge, well-maintained equipment, so unplanned downtime due to malfunctions is never a concern.

    Getting the Support You Need to Outsource Effectively

    You operate in a complex research landscape, and study managers must focus on a broad range of factors that include recruiting participants, training personnel, and coordinating study sites.

    Phase III studies can take place in more than several countries, which adds to the complexity of equipment needs for study managers.

    One of the strongest reasons to outsource your clinical trial equipment needs is a quality provider offers crucial project management services.

    The most competent rental equipment providers offer project managers who can reduce the odds of delay by:

  • Taking care of factors that can keep you from attending to mission-critical responsibilities related to the actual clinical trial.
  • Will handle time-consuming tasks like managing delivery and handling import and export issues for you
    Deal with compliance documentation requirements, and make sure all your equipment is to specification.
  • Most importantly, having someone who will ensure that your equipment is in place and ready to use when you need it, and where you need it.

    • Many Benefits of Clinical Trial Equipment Rental

    The ever-growing complexities associated with clinical trials make purchasing equipment an expensive and time-consuming affair that you can easily bypass with clinical trial equipment rental.

    You’ll benefit from not worrying about equipment maintenance, calibration, and technical support from multiple vendors. Rather than dealing with the regulatory and logistical issues associated with purchasing, you’ll enjoy the services of a provider-assigned project manager to handle these mission-critical roles and make sure SIV dates are met at all site locations.

    If you’re serious about your trial’s success, visit Axelerist Financial. With 30 years of experience supplying essential clinical trial equipment for clinical trials anywhere in the world and our outstanding 24/7 customer service, we make working with the latest equipment easy and cost-effective.

  • The Advantages of Leasing IT Equipment

    The Advantages of Leasing IT Equipment

    Given the speed at which technology develops these days, buying IT equipment outright can be counterproductive for companies. Not only does purchasing usually require significant capital expenditure, but frequent software updates also increase the risk of your expensive new hardware becoming less efficient — or even obsolete — sooner rather than later. Partnering with a provider to lease the equipment instead allows your company to reduce this risk while enjoying a number of other benefits.

    Financial Advantages

    Choosing to lease your IT equipment instead of buying it delivers significant financial advantages. Companies can reduce the total cost of ownership, have better control over cash flow, conserve working capital for business initiatives, and keep their lines of credit intact. Leasing seldom requires a downpayment and depending on the type of lease structured all rentals may be fully tax deductible.This method of financing reduces the liabilities listed on your company’s balance sheet.

    Equipment financing also hedges your inflation risk, according to the Equipment Leasing and Finance Association, by locking in the interest rate on the day of closing. When inflation devalues the payments over time, the difference is absorbed by the finance provider.

    Staying Updated

    Leasing offers a built-in renewal strategy for your IT assets, thanks to the option to upgrade equipment more regularly than if you were to purchase outright.

    This enables your company to take on new and diverse business opportunities without the concern that current equipment doesn’t have the right capabilities. Companies leasing IT equipment also benefit from lower maintenance and support costs, which the equipment typically incurs as it ages.

    Well-timed refresh cycles help enterprises to limit obsolete equipment while increasing employee efficiency and giving them the facilities to work effectively.

    Flexible Choices

    Businesses often need a combination of different equipment brands for their IT requirements. It can be challenging to source brands from multiple suppliers, but leasing offers a seamless alternative. Companies provide their equipment criteria to the finance provider, who can usually arrange to purchase the equipment from a number of different manufacturers for a monthly payment against a single lease agreement.

    Asset Disposal

    Getting rid of old IT equipment, which is classed as hazardous waste in many states, can be particularly difficult if companies have large quantities of it. Leasing equipment provides you with an easier way to dispose of old assets when they’re no longer useful as a good leasing provider should also handle equipment removal and disposal. The lessor should be responsible for all costs of removing and disposing of equipment in accordance with local, state and federal environmental compliance laws.

    A Viable Solution

    Leasing IT equipment offers multiple advantages for companies of every size and resolves most of the challenges associated with capital purchases. It enables you to maintain the high hardware standards required for your company systems and delivers both cost savings and efficiencies over the long term.

    If you’re ready to explore the benefits of your company’s future IT equipment leasing requirements, contact Axelerist to discover how we can help.

  • Why Trust Axelerist?

    Why Trust Axelerist?

    Having the right equipment is vital to the success of any project, whether it’s for a clinical trial, laboratory, or your organization’s IT department. It’s essential to not only source the best equipment but also to choose a solution that delivers the support you need.

    Here is why you can trust us to take care of all your leasing requirements.

    Our Experience Spans 30 Years

    With 30 years of experience in delivering leased and rented equipment, Axelerist currently has equipment in more than 40 countries and used in 100 active clinical trials. But clinical trials aren’t our only market served. There are three key areas where we can serve your business:

  • Clinical Trial Equipment – We lease equipment for every phase of clinical trials, we have a solid record of supplying the Life Sciences industry with the tools they need.
  • Laboratory Equipment – We also specialize in leasing equipment for laboratories and companies in pharma and biotech fields.
  • IT Equipment – Axelerist has a friction-free process in place to structure a custom, cost-effective leasing agreement on a range of IT products from your chosen IT supplier.

    • Our team recognizes the impact of making the right choice for your bottom line, and over the decades we’ve gathered a wealth of knowledge in all three of the industries above.

    We Protect Your Budgets

    Obtaining the necessary equipment for IT, clinical trials, or R&D projects is undeniably a costly undertaking. With Axelerist’s record of providing the absolute lowest prices in the industry, we’re confident our offering will save you 10-40% compared with competitors.

    Leasing tends to come at a lower cost than buying does. Our large inventory of items and partnerships with multiple manufacturers enables us to supply your organization directly with the technology brands you prefer. What’s more, we handle it all under a single lease agreement. Over the years, we’ve written leases with a total value of more than $500 million, and we know what it takes to structure a deal that gives you your money’s worth.

    When combined with our flexible term agreements — which range from 6 to 60 months — you’ll be able to achieve a significantly lower total cost of ownership and conserve capital, no matter the project type.

    Our Team Saves You Time

    No matter how well-planned your clinical trial or R&D project, time is always of the essence. The Axelerist team understands this, which is why we guarantee same day quotes and immediate turnarounds on orders. Once your order is received, an Axelerist project manager works to manage the details, freeing up your time so you can focus on project goals.

    When you need to act fast to secure a project outcome, we’re in your corner. We ensure that you get whatever you need, when and where you need it.

    We Deliver Unrivaled Support

    We make sure our representatives are available 24/7. But it doesn’t end there. You’ll find evidence of our unrivaled support in:

  • Immediate order turnarounds
  • An online customer portal that makes tracking your orders and contracts simple
  • Simple and straightforward communication with a dedicated project manager

    • We also enable you to stay ahead of equipment development, as leasing gives your company the flexibility to upgrade at any time to newly-released technology.

    Whether your project needs change or you simply require the latest, state-of-the-art equipment, leasing enables you to achieve this because you aren’t locked into the equipment you leased upfront.

    Rise to the Challenge

    The equipment rental industry is looking at significant expansion this year, according to the Equipment Leasing and Finance Foundation’s 2019 Economic Outlook report. Leasing is a sought after option as companies realize the benefits. With Axelerist at your side, your organization will be positioned for success on all of your projects.

    Want a risk-free, well-coordinated approach to equipment for your next project? Trust Axelerist to be your partner and see the benefits of our quality solutions.